PDX models reflect the proteome landscape of pediatric acute lymphoblastic leukemia but divert in se...
PDX models reflect the proteome landscape of pediatric acute lymphoblastic leukemia but divert in select pathways
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Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
Murine xenografts of pediatric leukemia accurately recapitulate genomic aberrations. How this translates to the functional capacity of cells remains unclear. Here, we studied global protein abundance, phosphorylation, and protein maturation by proteolytic processing in 11 pediatric B- and T- cell ALL patients and 19 corresponding xenografts.
Xen...
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Full title
PDX models reflect the proteome landscape of pediatric acute lymphoblastic leukemia but divert in select pathways
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TN_cdi_doaj_primary_oai_doaj_org_article_d322bf218f4945d68e9218ca550e6200
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d322bf218f4945d68e9218ca550e6200
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ISSN
1756-9966,0392-9078
E-ISSN
1756-9966
DOI
10.1186/s13046-021-01835-8
