The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation
The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
Superoxide dismutase-1 (SOD1) mutants, including those with unaltered enzymatic activity, are known to cause amyotrophic lateral sclerosis (ALS). Several destabilizing factors contribute to pathogenicity including a reduced ability to complete the normal maturation process which comprises folding, metal cofactor acquisition, intra-subunit disulphid...
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Full title
The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation
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TN_cdi_doaj_primary_oai_doaj_org_article_d39dd025e5674f268976de0edbd8107d
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d39dd025e5674f268976de0edbd8107d
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-04114-x
