Conjugates of Cryptophycin and RGD or isoDGR Peptidomimetics for Targeted Drug Delivery
Conjugates of Cryptophycin and RGD or isoDGR Peptidomimetics for Targeted Drug Delivery
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Publisher
Weinheim: John Wiley & Sons, Inc
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Language
English
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Publisher
Weinheim: John Wiley & Sons, Inc
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Contents
RGD‐cryptophycin and isoDGR‐cryptophycin conjugates were synthetized by combining peptidomimetic integrin ligands and cryptophycin, a highly potent tubulin‐binding antimitotic agent across lysosomally cleavable Val‐Ala or uncleavable linkers. The conjugates were able to effectively inhibit binding of biotinylated vitronectin to integrin αvβ3, showi...
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Full title
Conjugates of Cryptophycin and RGD or isoDGR Peptidomimetics for Targeted Drug Delivery
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TN_cdi_doaj_primary_oai_doaj_org_article_d3a79dc0bab74335b6cc1b9cbbeb2934
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d3a79dc0bab74335b6cc1b9cbbeb2934
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ISSN
2191-1363
E-ISSN
2191-1363
DOI
10.1002/open.201900110
