A p300/GATA6 axis determines differentiation and Wnt dependency in pancreatic cancer models
A p300/GATA6 axis determines differentiation and Wnt dependency in pancreatic cancer models
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United States: American Society for Clinical Investigation
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Language
English
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Publisher
United States: American Society for Clinical Investigation
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Contents
Wnt signaling regulates the balance between stemness and differentiation in multiple tissues and in cancer. RNF43-mutant pancreatic cancers are dependent on Wnt production, and pharmacologic blockade of the pathway, e.g., by PORCN inhibitors, leads to tumor differentiation. However, primary resistance to these inhibitors has been observed. To eluci...
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Full title
A p300/GATA6 axis determines differentiation and Wnt dependency in pancreatic cancer models
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TN_cdi_doaj_primary_oai_doaj_org_article_d3ac6d2f47d54c30923a44bed4508295
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d3ac6d2f47d54c30923a44bed4508295
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ISSN
1558-8238,0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI156305
