Dynamic regulation of mitochondrial pyruvate metabolism is necessary for orthotopic pancreatic tumor...
Dynamic regulation of mitochondrial pyruvate metabolism is necessary for orthotopic pancreatic tumor growth
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Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
Pyruvate dehydrogenase complex (PDC) plays a central role in carbohydrate metabolism, linking cytoplasmic glycolysis to the mitochondrial tricarboxylic acid (TCA) cycle. PDC is a conserved E1-E2-E3 dehydrogenase with a PDHA1 and PDHB heterotetramer functioning as the E1 subunit. PDHA1 contains three serine residues that can be reversibly phosphoryl...
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Full title
Dynamic regulation of mitochondrial pyruvate metabolism is necessary for orthotopic pancreatic tumor growth
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TN_cdi_doaj_primary_oai_doaj_org_article_d422a91c2933419ab609c3d888089031
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d422a91c2933419ab609c3d888089031
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ISSN
2049-3002
E-ISSN
2049-3002
DOI
10.1186/s40170-021-00275-4
