Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease
Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease
About this item
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Author / Creator
Douangamath, Alice , Fearon, Daren , Gehrtz, Paul , Krojer, Tobias , Lukacik, Petra , Owen, C. David , Resnick, Efrat , Strain-Damerell, Claire , Aimon, Anthony , Ábrányi-Balogh, Péter , Brandão-Neto, José , Carbery, Anna , Davison, Gemma , Dias, Alexandre , Downes, Thomas D. , Dunnett, Louise , Fairhead, Michael , Firth, James D. , Jones, S. Paul , Keeley, Aaron , Keserü, György M. , Klein, Hanna F. , Martin, Mathew P. , Noble, Martin E. M. , O’Brien, Peter , Powell, Ailsa , Reddi, Rambabu N. , Skyner, Rachael , Snee, Matthew , Waring, Michael J. , Wild, Conor , London, Nir , von Delft, Frank and Walsh, Martin A.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
COVID-19, caused by SARS-CoV-2, lacks effective therapeutics. Additionally, no antiviral drugs or vaccines were developed against the closely related coronavirus, SARS-CoV-1 or MERS-CoV, despite previous zoonotic outbreaks. To identify starting points for such therapeutics, we performed a large-scale screen of electrophile and non-covalent fragment...
Alternative Titles
Full title
Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease
Authors, Artists and Contributors
Author / Creator
Fearon, Daren
Gehrtz, Paul
Krojer, Tobias
Lukacik, Petra
Owen, C. David
Resnick, Efrat
Strain-Damerell, Claire
Aimon, Anthony
Ábrányi-Balogh, Péter
Brandão-Neto, José
Carbery, Anna
Davison, Gemma
Dias, Alexandre
Downes, Thomas D.
Dunnett, Louise
Fairhead, Michael
Firth, James D.
Jones, S. Paul
Keeley, Aaron
Keserü, György M.
Klein, Hanna F.
Martin, Mathew P.
Noble, Martin E. M.
O’Brien, Peter
Powell, Ailsa
Reddi, Rambabu N.
Skyner, Rachael
Snee, Matthew
Waring, Michael J.
Wild, Conor
London, Nir
von Delft, Frank
Walsh, Martin A.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_d499338758524d99942f9963faf75661
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d499338758524d99942f9963faf75661
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-18709-w
