A specific inhibitor of ALDH1A3 regulates retinoic acid biosynthesis in glioma stem cells
A specific inhibitor of ALDH1A3 regulates retinoic acid biosynthesis in glioma stem cells
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Author / Creator
Li, Jianfeng , Garavaglia, Silvia , Ye, Zhaofeng , Moretti, Andrea , Belyaeva, Olga V. , Beiser, Alison , Ibrahim, Md , Wilk, Anna , McClellan, Steve , Klyuyeva, Alla V. , Goggans, Kelli R. , Kedishvili, Natalia Y. , Salter, E. Alan , Wierzbicki, Andrzej , Migaud, Marie E. , Mullett, Steven J. , Yates, Nathan A. , Camacho, Carlos J. , Rizzi, Menico and Sobol, Robert W.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Elevated aldehyde dehydrogenase (ALDH) activity correlates with poor outcome for many solid tumors as ALDHs may regulate cell proliferation and chemoresistance of cancer stem cells (CSCs). Accordingly, potent, and selective inhibitors of key ALDH enzymes may represent a novel CSC-directed treatment paradigm for ALDH
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cancer types. Of the man...
Alternative Titles
Full title
A specific inhibitor of ALDH1A3 regulates retinoic acid biosynthesis in glioma stem cells
Authors, Artists and Contributors
Author / Creator
Garavaglia, Silvia
Ye, Zhaofeng
Moretti, Andrea
Belyaeva, Olga V.
Beiser, Alison
Ibrahim, Md
Wilk, Anna
McClellan, Steve
Klyuyeva, Alla V.
Goggans, Kelli R.
Kedishvili, Natalia Y.
Salter, E. Alan
Wierzbicki, Andrzej
Migaud, Marie E.
Mullett, Steven J.
Yates, Nathan A.
Camacho, Carlos J.
Rizzi, Menico
Sobol, Robert W.
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_d4ab4bd6ea5d4fe5ac3e294cb177d517
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d4ab4bd6ea5d4fe5ac3e294cb177d517
Other Identifiers
ISSN
2399-3642
E-ISSN
2399-3642
DOI
10.1038/s42003-021-02949-7
