ASCL1 activates neuronal stem cell-like lineage programming through remodeling of the chromatin land...
ASCL1 activates neuronal stem cell-like lineage programming through remodeling of the chromatin landscape in prostate cancer
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
Treatment with androgen receptor pathway inhibitors (ARPIs) in prostate cancer leads to the emergence of resistant tumors characterized by lineage plasticity and differentiation toward neuroendocrine lineage. Here, we find that ARPIs induce a rapid epigenetic alteration mediated by large-scale chromatin remodeling to support activation of stem/neur...
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Full title
ASCL1 activates neuronal stem cell-like lineage programming through remodeling of the chromatin landscape in prostate cancer
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TN_cdi_doaj_primary_oai_doaj_org_article_d4c48d0f84e74da9bf7129acd29bbc7f
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d4c48d0f84e74da9bf7129acd29bbc7f
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-29963-5
