Targeting MC1R depalmitoylation to prevent melanomagenesis in redheads
Targeting MC1R depalmitoylation to prevent melanomagenesis in redheads
About this item
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Author / Creator
Chen, Shuyang , Han, Changpeng , Miao, Xiao , Li, Xin , Yin, Chengqian , Zou, Junrong , Liu, Min , Li, Shanshan , Stawski, Lukasz , Zhu, Bo , Shi, Qiong , Xu, Zhi-Xiang , Li, Chunying , Goding, Colin R. , Zhou, Jun and Cui, Rutao
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Some genetic melanocortin-1 receptor (MC1R) variants responsible for human red hair color (RHC-variants) are consequently associated with increased melanoma risk. Although MC1R signaling is critically dependent on its palmitoylation primarily mediated by the ZDHHC13 protein-acyl transferase, whether increasing MC1R palmitoylation represents a viabl...
Alternative Titles
Full title
Targeting MC1R depalmitoylation to prevent melanomagenesis in redheads
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_d4cb91d255ff4330b7ffd8d024fa1867
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d4cb91d255ff4330b7ffd8d024fa1867
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-08691-3
