Duodenum Intestine-Chip for preclinical drug assessment in a human relevant model
Duodenum Intestine-Chip for preclinical drug assessment in a human relevant model
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Publisher
England: eLife Science Publications, Ltd
Journal title
Language
English
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Publisher
England: eLife Science Publications, Ltd
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Contents
Induction of intestinal drug metabolizing enzymes can complicate the development of new drugs, owing to the potential to cause drug-drug interactions (DDIs) leading to changes in pharmacokinetics, safety and efficacy. The development of a human-relevant model of the adult intestine that accurately predicts CYP450 induction could help address this c...
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Full title
Duodenum Intestine-Chip for preclinical drug assessment in a human relevant model
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TN_cdi_doaj_primary_oai_doaj_org_article_d50dcbcf666140a997178741be620615
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d50dcbcf666140a997178741be620615
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.50135
