Reversible histone glycation is associated with disease-related changes in chromatin architecture
Reversible histone glycation is associated with disease-related changes in chromatin architecture
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Cellular proteins continuously undergo non-enzymatic covalent modifications (NECMs) that accumulate under normal physiological conditions and are stimulated by changes in the cellular microenvironment. Glycation, the hallmark of diabetes, is a prevalent NECM associated with an array of pathologies. Histone proteins are particularly susceptible to N...
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Full title
Reversible histone glycation is associated with disease-related changes in chromatin architecture
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TN_cdi_doaj_primary_oai_doaj_org_article_d549df8147a043739d0eb71b8d597555
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d549df8147a043739d0eb71b8d597555
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-09192-z
