Discovery of Quinacrine as a Potent Topo II and Hsp90 Dual-Target Inhibitor, Repurposing for Cancer...
Discovery of Quinacrine as a Potent Topo II and Hsp90 Dual-Target Inhibitor, Repurposing for Cancer Therapy
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Basel: MDPI AG
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Language
English
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Publisher
Basel: MDPI AG
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Topo II and Hsp90 are promising targets. In this study, we first verified the structural similarities between Topo IIα ATPase and Hsp90α N−ATPase. Subsequently, 720 compounds from the Food and Drug Administration (FDA) drug library and kinase library were screened using the malachite green phosphate combination with the Topo II-mediated DNA relaxat...
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Full title
Discovery of Quinacrine as a Potent Topo II and Hsp90 Dual-Target Inhibitor, Repurposing for Cancer Therapy
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TN_cdi_doaj_primary_oai_doaj_org_article_d57ae07bd94249d987c71b314455d0d3
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d57ae07bd94249d987c71b314455d0d3
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ISSN
1420-3049
E-ISSN
1420-3049
DOI
10.3390/molecules27175561
