Small molecule inhibition of 6-phosphofructo-2-kinase suppresses t cell activation
Small molecule inhibition of 6-phosphofructo-2-kinase suppresses t cell activation
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Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
T cell activation is associated with a rapid increase in intracellular fructose-2,6-bisphosphate (F2,6BP), an allosteric activator of the glycolytic enzyme, 6-phosphofructo-1-kinase. The steady state concentration of F2,6BP in T cells is dependent on the expression of the bifunctional 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases (PFKFB1-4)...
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Full title
Small molecule inhibition of 6-phosphofructo-2-kinase suppresses t cell activation
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TN_cdi_doaj_primary_oai_doaj_org_article_d5aed3bb56584cc88c045dc49036d83b
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d5aed3bb56584cc88c045dc49036d83b
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ISSN
1479-5876
E-ISSN
1479-5876
DOI
10.1186/1479-5876-10-95
