Pancreatic cancer acquires resistance to MAPK pathway inhibition by clonal expansion and adaptive DN...
Pancreatic cancer acquires resistance to MAPK pathway inhibition by clonal expansion and adaptive DNA hypermethylation
About this item
Full title
Author / Creator
Godfrey, Laura K. , Forster, Jan , Liffers, Sven-Thorsten , Schröder, Christopher , Köster, Johannes , Henschel, Leonie , Ludwig, Kerstin U. , Lähnemann, David , Trajkovic-Arsic, Marija , Behrens, Diana , Scarpa, Aldo , Lawlor, Rita T. , Witzke, Kathrin E. , Sitek, Barbara , Johnsen, Steven A. , Rahmann, Sven , Horsthemke, Bernhard , Zeschnigk, Michael and Siveke, Jens T.
Publisher
Germany: BioMed Central Ltd
Journal title
Language
English
Formats
Publication information
Publisher
Germany: BioMed Central Ltd
Subjects
More information
Scope and Contents
Contents
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with poor prognosis. It is marked by extraordinary resistance to conventional therapies including chemotherapy and radiation, as well as to essentially all targeted therapies evaluated so far. More than 90% of PDAC cases harbor an activating KRAS mutation. As the most common KRAS varia...
Alternative Titles
Full title
Pancreatic cancer acquires resistance to MAPK pathway inhibition by clonal expansion and adaptive DNA hypermethylation
Authors, Artists and Contributors
Author / Creator
Forster, Jan
Liffers, Sven-Thorsten
Schröder, Christopher
Köster, Johannes
Henschel, Leonie
Ludwig, Kerstin U.
Lähnemann, David
Trajkovic-Arsic, Marija
Behrens, Diana
Scarpa, Aldo
Lawlor, Rita T.
Witzke, Kathrin E.
Sitek, Barbara
Johnsen, Steven A.
Rahmann, Sven
Horsthemke, Bernhard
Zeschnigk, Michael
Siveke, Jens T.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_d600d9b4f409474cb363cc7b8d335cf3
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d600d9b4f409474cb363cc7b8d335cf3
Other Identifiers
ISSN
1868-7083,1868-7075
E-ISSN
1868-7083,1868-7075
DOI
10.1186/s13148-024-01623-z
