Multiplexed engineering glycosyltransferase genes in CHO cells via targeted integration for producin...
Multiplexed engineering glycosyltransferase genes in CHO cells via targeted integration for producing antibodies with diverse complex-type N-glycans
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
Therapeutic antibodies are decorated with complex-type N-glycans that significantly affect their biodistribution and bioactivity. The N-glycan structures on antibodies are incompletely processed in wild-type CHO cells due to their limited glycosylation capacity. To improve N-glycan processing, glycosyltransferase genes have been traditionally overe...
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Full title
Multiplexed engineering glycosyltransferase genes in CHO cells via targeted integration for producing antibodies with diverse complex-type N-glycans
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TN_cdi_doaj_primary_oai_doaj_org_article_d6016d0862bc4687baedcd7b078f5685
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d6016d0862bc4687baedcd7b078f5685
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-021-92320-x
