CK2-induced cooperation of HHEX with the YAP-TEAD4 complex promotes colorectal tumorigenesis
CK2-induced cooperation of HHEX with the YAP-TEAD4 complex promotes colorectal tumorigenesis
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Author / Creator
Guo, Yuegui , Zhu, Zhehui , Huang, Zhenyu , Cui, Long , Yu, Wei , Hong, Wanjin , Zhou, Zhaocai , Du, Peng and Liu, Chen-Ying
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Dysregulation of Hippo pathway leads to hyperactivation of YAP-TEAD transcriptional complex in various cancers, including colorectal cancer (CRC). In this study, we observed that HHEX (Hematopoietically expressed homeobox) may enhance transcription activity of the YAP-TEAD complex. HHEX associates with and stabilizes the YAP-TEAD complex on the reg...
Alternative Titles
Full title
CK2-induced cooperation of HHEX with the YAP-TEAD4 complex promotes colorectal tumorigenesis
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_d618908aad7044e49433c6f1f82f84b6
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d618908aad7044e49433c6f1f82f84b6
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-32674-6
