Brain milieu induces early microglial maturation through the BAX-Notch axis
Brain milieu induces early microglial maturation through the BAX-Notch axis
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Author / Creator
Zhao, Fangying , He, Jiangyong , Tang, Jun , Cui, Nianfei , Shi, Yanyan , Li, Zhifan , Liu, Shengnan , Wang, Yazhou , Ma, Ming , Zhao, Congjian , Luo, Lingfei and Li, Li
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Contents
Microglia are derived from primitive myeloid cells and gain their early identity in the embryonic brains. However, the mechanism by which the brain milieu confers microglial maturation signature remains elusive. Here, we demonstrate that the
bax
cq55
zebrafish and
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mouse embryos exhibit similarly defective early microgli...
Alternative Titles
Full title
Brain milieu induces early microglial maturation through the BAX-Notch axis
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TN_cdi_doaj_primary_oai_doaj_org_article_d62917e10b904fa8906bc5d473132c3c
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d62917e10b904fa8906bc5d473132c3c
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-33836-2
