Camel nanobody-based B7-H3 CAR-T cells show high efficacy against large solid tumours
Camel nanobody-based B7-H3 CAR-T cells show high efficacy against large solid tumours
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Rational design of chimeric antigen receptor T (CAR-T) cells based on the recognition of antigenic epitopes capable of evoking the most potent CAR activation is an important objective in optimizing immune therapy. In solid tumors, the B7-H3 transmembrane protein is an emerging target that harbours two distinct epitope motifs, IgC and IgV, in its ec...
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Camel nanobody-based B7-H3 CAR-T cells show high efficacy against large solid tumours
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TN_cdi_doaj_primary_oai_doaj_org_article_d633e7c59ca149f7b0f28503297c8880
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d633e7c59ca149f7b0f28503297c8880
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-41631-w
