A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation
A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation
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Author / Creator
Kim, Jung-Min , Yang, Yeon-Suk , Park, Kwang Hwan , Ge, Xianpeng , Xu, Ren , Li, Na , Song, Minkyung , Chun, Hyunho , Bok, Seoyeon , Charles, Julia F. , Filhol-Cochet, Odile , Boldyreff, Brigitte , Dinter, Teresa , Yu, Paul B. , Kon, Ning , Gu, Wei , Takarada, Takeshi , Greenblatt, Matthew B. and Shim, Jae-Hyuck
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Contents
The osteoblast differentiation capacity of skeletal stem cells (SSCs) must be tightly regulated, as inadequate bone formation results in low bone mass and skeletal fragility, and over-exuberant osteogenesis results in heterotopic ossification (HO) of soft tissues. RUNX2 is essential for tuning this balance, but the mechanisms of posttranslational c...
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Full title
A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation
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TN_cdi_doaj_primary_oai_doaj_org_article_d66c7cf3ddb9472bb8083540eab23003
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d66c7cf3ddb9472bb8083540eab23003
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-16038-6
