A Klotho-derived peptide protects against kidney fibrosis by targeting TGF-β signaling
A Klotho-derived peptide protects against kidney fibrosis by targeting TGF-β signaling
About this item
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Author / Creator
Yuan, Qian , Ren, Qian , Li, Li , Tan, Huishi , Lu, Meizhi , Tian, Yuan , Huang, Lu , Zhao, Boxin , Fu, Haiyan , Hou, Fan Fan , Zhou, Lili and Liu, Youhua
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Loss of Klotho, an anti-aging protein, plays a critical role in the pathogenesis of chronic kidney diseases. As Klotho is a large transmembrane protein, it is challenging to harness it as a therapeutic remedy. Here we report the discovery of a Klotho-derived peptide 1 (KP1) protecting kidneys by targeting TGF-β signaling. By screening a series of p...
Alternative Titles
Full title
A Klotho-derived peptide protects against kidney fibrosis by targeting TGF-β signaling
Authors, Artists and Contributors
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_d66dc43029e6430ab62993785503a192
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d66dc43029e6430ab62993785503a192
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-28096-z
