Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcr...
Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Tissue and vessel wall stiffening alters endothelial cell properties and contributes to vascular dysfunction. However, whether extracellular matrix (ECM) stiffness impacts vascular development is not known. Here we show that matrix stiffness controls lymphatic vascular morphogenesis. Atomic force microscopy measurements in mouse embryos reveal that...
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Full title
Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program
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TN_cdi_doaj_primary_oai_doaj_org_article_d7157b72d40e47f885661cb7f76b2542
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d7157b72d40e47f885661cb7f76b2542
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-03959-6
