BR2 cell penetrating peptide effectively delivers anti-p21Ras scFv to tumor cells with ganglioside e...
BR2 cell penetrating peptide effectively delivers anti-p21Ras scFv to tumor cells with ganglioside expression for therapy of ras-driven tumor
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Author / Creator
Ting Yu , Yingxian Shi , Xinyan Pan , Qiang Feng , Peng Wang , Shuling Song , Lilin Yang and Julun Yang
Publisher
Public Library of Science (PLoS)
Journal title
Language
English
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Publisher
Public Library of Science (PLoS)
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PurposeCell membrane penetrating peptide BR2 can bind with ganglioside and introduce foreign drugs into tumor cells. In this study, we employed BR2 to carry the broad-spectrum anti-p21Ras scFv prepared in our laboratory into ganglioside expressing tumor cells for therapy of ras-driven tumors.MethodsBR2-p21Ras scFv gene was cloned to prokaryotic exp...
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Full title
BR2 cell penetrating peptide effectively delivers anti-p21Ras scFv to tumor cells with ganglioside expression for therapy of ras-driven tumor
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TN_cdi_doaj_primary_oai_doaj_org_article_d737aac468ea4e29bed253d495e4d60d
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d737aac468ea4e29bed253d495e4d60d
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E-ISSN
1932-6203
DOI
10.1371/journal.pone.0269084
