Human CLEC9A antibodies deliver Wilms' tumor 1 (WT1) antigen to CD141+ dendritic cells to activate n...
Human CLEC9A antibodies deliver Wilms' tumor 1 (WT1) antigen to CD141+ dendritic cells to activate naïve and memory WT1‐specific CD8+ T cells
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Author / Creator
Pearson, Frances E , Tullett, Kirsteen M , Leal‐Rojas, Ingrid M , Haigh, Oscar L , Masterman, Kelly‐Anne , Walpole, Carina , Bridgeman, John S , McLaren, James E , Ladell, Kristin , Miners, Kelly , Llewellyn‐Lacey, Sian , Price, David A , Tunger, Antje , Schmitz, Marc , Miles, John J , Lahoud, Mireille H and Radford, Kristen J
Publisher
Australia: John Wiley & Sons, Inc
Journal title
Language
English
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Publisher
Australia: John Wiley & Sons, Inc
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Scope and Contents
Contents
Objectives
Vaccines that prime Wilms' tumor 1 (WT1)‐specific CD8+ T cells are attractive cancer immunotherapies. However, immunogenicity and clinical response rates may be enhanced by delivering WT1 to CD141+ dendritic cells (DCs). The C‐type lectin‐like receptor CLEC9A is expressed exclusively by CD141+ DCs and regulates CD8+ T‐cell responses....
Alternative Titles
Full title
Human CLEC9A antibodies deliver Wilms' tumor 1 (WT1) antigen to CD141+ dendritic cells to activate naïve and memory WT1‐specific CD8+ T cells
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Author / Creator
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_d7716a6649ca41f9a6290ec9da9eae79
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d7716a6649ca41f9a6290ec9da9eae79
Other Identifiers
ISSN
2050-0068
E-ISSN
2050-0068
DOI
10.1002/cti2.1141
