Activation of RAS/MAPK pathway confers MCL-1 mediated acquired resistance to BCL-2 inhibitor venetoc...
Activation of RAS/MAPK pathway confers MCL-1 mediated acquired resistance to BCL-2 inhibitor venetoclax in acute myeloid leukemia
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Author / Creator
Zhang, Qi , Riley-Gillis, Bridget , Han, Lina , Jia, Yannan , Lodi, Alessia , Zhang, Haijiao , Ganesan, Saravanan , Pan, Rongqing , Konoplev, Sergej N. , Sweeney, Shannon R. , Ryan, Jeremy A. , Jitkova, Yulia , Dunner, Kenneth , Grosskurth, Shaun E. , Vijay, Priyanka , Ghosh, Sujana , Lu, Charles , Ma, Wencai , Kurtz, Stephen , Ruvolo, Vivian R. , Ma, Helen , Weng, Connie C. , Ramage, Cassandra L. , Baran, Natalia , Shi, Ce , Cai, Tianyu , Davis, Richard Eric , Battula, Venkata L. , Mi, Yingchang , Wang, Jing , DiNardo, Courtney D. , Andreeff, Michael , Tyner, Jeffery W. , Schimmer, Aaron , Letai, Anthony , Padua, Rose Ann , Bueso-Ramos, Carlos E. , Tiziani, Stefano , Leverson, Joel , Popovic, Relja and Konopleva, Marina
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Despite high initial response rates, acute myeloid leukemia (AML) treated with the BCL-2–selective inhibitor venetoclax (VEN) alone or in combinations commonly acquires resistance. We performed gene/protein expression, metabolomic and methylation analyses of isogenic AML cell lines sensitive or resistant to VEN, and identified the activation of RAS...
Alternative Titles
Full title
Activation of RAS/MAPK pathway confers MCL-1 mediated acquired resistance to BCL-2 inhibitor venetoclax in acute myeloid leukemia
Authors, Artists and Contributors
Author / Creator
Riley-Gillis, Bridget
Han, Lina
Jia, Yannan
Lodi, Alessia
Zhang, Haijiao
Ganesan, Saravanan
Pan, Rongqing
Konoplev, Sergej N.
Sweeney, Shannon R.
Ryan, Jeremy A.
Jitkova, Yulia
Dunner, Kenneth
Grosskurth, Shaun E.
Vijay, Priyanka
Ghosh, Sujana
Lu, Charles
Ma, Wencai
Kurtz, Stephen
Ruvolo, Vivian R.
Ma, Helen
Weng, Connie C.
Ramage, Cassandra L.
Baran, Natalia
Shi, Ce
Cai, Tianyu
Davis, Richard Eric
Battula, Venkata L.
Mi, Yingchang
Wang, Jing
DiNardo, Courtney D.
Andreeff, Michael
Tyner, Jeffery W.
Schimmer, Aaron
Letai, Anthony
Padua, Rose Ann
Bueso-Ramos, Carlos E.
Tiziani, Stefano
Leverson, Joel
Popovic, Relja
Konopleva, Marina
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_d7945566353e4cff944fa98c53fc192d
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d7945566353e4cff944fa98c53fc192d
Other Identifiers
ISSN
2059-3635,2095-9907
E-ISSN
2059-3635
DOI
10.1038/s41392-021-00870-3
