Deciphering downstream gene targets of PI3K/mTOR/p70S6K pathway in breast cancer
Deciphering downstream gene targets of PI3K/mTOR/p70S6K pathway in breast cancer
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Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
The 70 kDa ribosomal protein S6 kinase (RPS6KB1), located at 17q23, is amplified and overexpressed in 10-30% of primary breast cancers and breast cancer cell lines. p70S6K is a serine/threonine kinase regulated by PI3K/mTOR pathway, which plays a crucial role in control of cell cycle, growth and survival. Our aim was to determine p70S6K and PI3K/mT...
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Full title
Deciphering downstream gene targets of PI3K/mTOR/p70S6K pathway in breast cancer
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TN_cdi_doaj_primary_oai_doaj_org_article_d7d8982824a54484bd5e9de9ddf88b16
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d7d8982824a54484bd5e9de9ddf88b16
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ISSN
1471-2164
E-ISSN
1471-2164
DOI
10.1186/1471-2164-9-348
