A highly conserved sequence of the viral TAP inhibitor ICP47 is required for freezing of the peptide...
A highly conserved sequence of the viral TAP inhibitor ICP47 is required for freezing of the peptide transport cycle
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The transporter associated with antigen processing (TAP) translocates antigenic peptides into the endoplasmic reticulum (ER) lumen for loading onto MHC class I molecules. This is a key step in the control of viral infections through CD8+ T-cells. The herpes simplex virus type-1 encodes an 88 amino acid long species-specific TAP inhibitor, ICP47, th...
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Full title
A highly conserved sequence of the viral TAP inhibitor ICP47 is required for freezing of the peptide transport cycle
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TN_cdi_doaj_primary_oai_doaj_org_article_d8467302d44249fdb0099d71445a063d
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d8467302d44249fdb0099d71445a063d
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-017-02994-5
