Dietary restriction of cysteine and methionine sensitizes gliomas to ferroptosis and induces alterat...
Dietary restriction of cysteine and methionine sensitizes gliomas to ferroptosis and induces alterations in energetic metabolism
About this item
Full title
Author / Creator
Upadhyayula, Pavan S. , Higgins, Dominique M. , Mela, Angeliki , Banu, Matei , Dovas, Athanassios , Zandkarimi, Fereshteh , Patel, Purvi , Mahajan, Aayushi , Humala, Nelson , Nguyen, Trang T. T. , Chaudhary, Kunal R. , Liao, Lillian , Argenziano, Michael , Sudhakar, Tejaswi , Sperring, Colin P. , Shapiro, Benjamin L. , Ahmed, Eman R. , Kinslow, Connor , Ye, Ling F. , Siegelin, Markus D. , Cheng, Simon , Soni, Rajesh , Bruce, Jeffrey N. , Stockwell, Brent R. and Canoll, Peter
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Ferroptosis is mediated by lipid peroxidation of phospholipids containing polyunsaturated fatty acyl moieties. Glutathione, the key cellular antioxidant capable of inhibiting lipid peroxidation via the activity of the enzyme glutathione peroxidase 4 (GPX-4), is generated directly from the sulfur-containing amino acid cysteine, and indirectly from m...
Alternative Titles
Full title
Dietary restriction of cysteine and methionine sensitizes gliomas to ferroptosis and induces alterations in energetic metabolism
Authors, Artists and Contributors
Author / Creator
Higgins, Dominique M.
Mela, Angeliki
Banu, Matei
Dovas, Athanassios
Zandkarimi, Fereshteh
Patel, Purvi
Mahajan, Aayushi
Humala, Nelson
Nguyen, Trang T. T.
Chaudhary, Kunal R.
Liao, Lillian
Argenziano, Michael
Sudhakar, Tejaswi
Sperring, Colin P.
Shapiro, Benjamin L.
Ahmed, Eman R.
Kinslow, Connor
Ye, Ling F.
Siegelin, Markus D.
Cheng, Simon
Soni, Rajesh
Bruce, Jeffrey N.
Stockwell, Brent R.
Canoll, Peter
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_d887ba793f1142b985b1d97d66d45514
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d887ba793f1142b985b1d97d66d45514
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-36630-w
