BCL-XL directly modulates RAS signalling to favour cancer cell stemness
BCL-XL directly modulates RAS signalling to favour cancer cell stemness
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Author / Creator
Carné Trécesson, Sophie de , Souazé, Frédérique , Basseville, Agnès , Bernard, Anne-Charlotte , Pécot, Jessie , Lopez, Jonathan , Bessou, Margaux , Sarosiek, Kristopher A. , Letai, Anthony , Barillé-Nion, Sophie , Valo, Isabelle , Coqueret, Olivier , Guette, Catherine , Campone, Mario , Gautier, Fabien and Juin, Philippe Paul
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
In tumours, accumulation of chemoresistant cells that express high levels of anti-apoptotic proteins such as BCL-X
L
is thought to result from the counter selection of sensitive, low expresser clones during progression and/or initial treatment. We herein show that BCL-X
L
expression is selectively advantageous to cancer cell populations...
Alternative Titles
Full title
BCL-XL directly modulates RAS signalling to favour cancer cell stemness
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_d8e0c073724f4c88b43e7f5e0debd8b0
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d8e0c073724f4c88b43e7f5e0debd8b0
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-017-01079-1
