Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisyst...
Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses
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Author / Creator
Kapeli, Katannya , Pratt, Gabriel A. , Vu, Anthony Q. , Hutt, Kasey R. , Martinez, Fernando J. , Sundararaman, Balaji , Batra, Ranjan , Freese, Peter , Lambert, Nicole J. , Huelga, Stephanie C. , Chun, Seung J. , Liang, Tiffany Y. , Chang, Jeremy , Donohue, John P. , Shiue, Lily , Zhang, Jiayu , Zhu, Haining , Cambi, Franca , Kasarskis, Edward , Hoon, Shawn , Ares Jr, Manuel , Burge, Christopher B. , Ravits, John , Rigo, Frank and Yeo, Gene W.
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
The RNA-binding protein (RBP) TAF15 is implicated in amyotrophic lateral sclerosis (ALS). To compare TAF15 function to that of two ALS-associated RBPs, FUS and TDP-43, we integrate CLIP-seq and RNA Bind-N-Seq technologies, and show that TAF15 binds to ∼4,900 RNAs enriched for GGUA motifs in adult mouse brains. TAF15 and FUS exhibit similar binding...
Alternative Titles
Full title
Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses
Authors, Artists and Contributors
Author / Creator
Pratt, Gabriel A.
Vu, Anthony Q.
Hutt, Kasey R.
Martinez, Fernando J.
Sundararaman, Balaji
Batra, Ranjan
Freese, Peter
Lambert, Nicole J.
Huelga, Stephanie C.
Chun, Seung J.
Liang, Tiffany Y.
Chang, Jeremy
Donohue, John P.
Shiue, Lily
Zhang, Jiayu
Zhu, Haining
Cambi, Franca
Kasarskis, Edward
Hoon, Shawn
Ares Jr, Manuel
Burge, Christopher B.
Ravits, John
Rigo, Frank
Yeo, Gene W.
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_d8f4356db05e4c6e9ae5ac8588f8d310
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d8f4356db05e4c6e9ae5ac8588f8d310
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms12143
