Biased action of the CXCR4-targeting drug plerixafor is essential for its superior hematopoietic ste...
Biased action of the CXCR4-targeting drug plerixafor is essential for its superior hematopoietic stem cell mobilization
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Following the FDA-approval of the hematopoietic stem cell (HSC) mobilizer plerixafor, orally available and potent CXCR4 antagonists were pursued. One such proposition was AMD11070, which was orally active and had superior antagonism in vitro; however, it did not appear as effective for HSC mobilization in vivo. Here we show that while AMD11070 acts...
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Biased action of the CXCR4-targeting drug plerixafor is essential for its superior hematopoietic stem cell mobilization
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TN_cdi_doaj_primary_oai_doaj_org_article_d920693ad8d842c78b29bd1b15141947
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d920693ad8d842c78b29bd1b15141947
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ISSN
2399-3642
E-ISSN
2399-3642
DOI
10.1038/s42003-021-02070-9
