Monitoring autochthonous lung tumors induced by somatic CRISPR gene editing in mice using a secreted...
Monitoring autochthonous lung tumors induced by somatic CRISPR gene editing in mice using a secreted luciferase
About this item
Full title
Author / Creator
Merle, Nastasja , Elmshäuser, Sabrina , Strassheimer, Florian , Wanzel, Michael , König, Alexander M , Funk, Julianne , Neumann, Michelle , Kochhan, Katharina , Helmprobst, Frederik , Pagenstecher, Axel , Nist, Andrea , Mernberger, Marco , Schneider, André , Braun, Thomas , Borggrefe, Tilman , Savai, Rajkumar , Timofeev, Oleg and Stiewe, Thorsten
Publisher
London: BioMed Central Ltd
Journal title
Language
English
Formats
Publication information
Publisher
London: BioMed Central Ltd
Subjects
More information
Scope and Contents
Contents
Background In vivo gene editing of somatic cells with CRISPR nucleases has facilitated the generation of autochthonous mouse tumors, which are initiated by genetic alterations relevant to the human disease and progress along a natural timeline as in patients. However, the long and variable, orthotopic tumor growth in inner organs requires sophistic...
Alternative Titles
Full title
Monitoring autochthonous lung tumors induced by somatic CRISPR gene editing in mice using a secreted luciferase
Authors, Artists and Contributors
Author / Creator
Elmshäuser, Sabrina
Strassheimer, Florian
Wanzel, Michael
König, Alexander M
Funk, Julianne
Neumann, Michelle
Kochhan, Katharina
Helmprobst, Frederik
Pagenstecher, Axel
Nist, Andrea
Mernberger, Marco
Schneider, André
Braun, Thomas
Borggrefe, Tilman
Savai, Rajkumar
Timofeev, Oleg
Stiewe, Thorsten
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_d980d18d5f1b484f966f534df0c944fb
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d980d18d5f1b484f966f534df0c944fb
Other Identifiers
ISSN
1476-4598
E-ISSN
1476-4598
DOI
10.1186/s12943-022-01661-2
