1072 GI-108, a novel bispecific fusion protein augments anti-tumor immunity by alleviating immunosup...
1072 GI-108, a novel bispecific fusion protein augments anti-tumor immunity by alleviating immunosuppressive adenosine pathway in CD8+ T cells
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Author / Creator
Shin, Kayoung , Park, Min , Kim, Seoho , Lee, Haejong , Lee, Yuseong , Kim, Jongil , Park, Suyoun , Kim, Jisoo , Lee, Eunjin , Lee, Sanghee , Lee, Kyungwha , Park, Chong Woo , Oh, Young Min , Lee, Wonjae , Ha, Danbee , Shim, Yaein Amy , Cho, Young-Gyu , Koh, Young Jun , Kim, Kookhwan and Jang, Myoung Ho
Publisher
London: BMJ Publishing Group Ltd
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Language
English
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Publisher
London: BMJ Publishing Group Ltd
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Contents
BackgroundCD73, a pivotal ectoenzyme responsible for the conversion of adenosine monophosphate (AMP) to adenosine, exhibits widespread expression on tumor cells and promotes accumulation of adenosine within the tumor microenvironment (TME). Adenosine acts as a potent immunomodulatory factor, effectively attenuating anti-tumor immune responses in th...
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Full title
1072 GI-108, a novel bispecific fusion protein augments anti-tumor immunity by alleviating immunosuppressive adenosine pathway in CD8+ T cells
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TN_cdi_doaj_primary_oai_doaj_org_article_d98510c4178c42c681f1c2956c74a6d1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d98510c4178c42c681f1c2956c74a6d1
Other Identifiers
E-ISSN
2051-1426
DOI
10.1136/jitc-2023-SITC2023.1072
