A Journey through Diastereomeric Space: The Design, Synthesis, In Vitro and In Vivo Pharmacological...
A Journey through Diastereomeric Space: The Design, Synthesis, In Vitro and In Vivo Pharmacological Activity, and Molecular Modeling of Novel Potent Diastereomeric MOR Agonists and Antagonists
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Basel: MDPI AG
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Language
English
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Basel: MDPI AG
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Contents
Four sets of diastereomeric C9-alkenyl 5-phenylmorphans, varying in the length of the C9-alkenyl chain, were designed to examine the effect of these spatially distinct ligands on opioid receptors. Functional activity was obtained by forskolin-induced cAMP accumulation assays and several compounds were examined in the [35S]GTPgS assay and in an assa...
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Full title
A Journey through Diastereomeric Space: The Design, Synthesis, In Vitro and In Vivo Pharmacological Activity, and Molecular Modeling of Novel Potent Diastereomeric MOR Agonists and Antagonists
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TN_cdi_doaj_primary_oai_doaj_org_article_d9c38bdcc69f493eb1644c1632588662
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d9c38bdcc69f493eb1644c1632588662
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ISSN
1420-3049
E-ISSN
1420-3049
DOI
10.3390/molecules27196455
