The ubiquitin ligase Cul5 regulates CD4+ T cell fate choice and allergic inflammation
The ubiquitin ligase Cul5 regulates CD4+ T cell fate choice and allergic inflammation
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Antigen encounter directs CD4
+
T cells to differentiate into T helper or regulatory cells. This process focuses the immune response on the invading pathogen and limits tissue damage. Mechanisms that govern T helper cell versus T regulatory cell fate remain poorly understood. Here, we show that the E3 ubiquitin ligase Cul5 determines fate sel...
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Full title
The ubiquitin ligase Cul5 regulates CD4+ T cell fate choice and allergic inflammation
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TN_cdi_doaj_primary_oai_doaj_org_article_d9e5115c68644de29848a0530e463a6f
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d9e5115c68644de29848a0530e463a6f
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-30437-x
