DNA translocation mechanism of the MCM complex and implications for replication initiation
DNA translocation mechanism of the MCM complex and implications for replication initiation
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The DNA translocation activity of the minichromosome maintenance (MCM) complex powers DNA strand separation of the replication forks of eukaryotes and archaea. Here we illustrate an atomic level mechanism for this activity with a crystal structure of an archaeal MCM hexamer bound to single-stranded DNA and nucleotide cofactors. Sequence conservatio...
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DNA translocation mechanism of the MCM complex and implications for replication initiation
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TN_cdi_doaj_primary_oai_doaj_org_article_da3d2f86275a48fca8e4523d176c6988
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_da3d2f86275a48fca8e4523d176c6988
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-11074-3
