Promotion of mitochondrial biogenesis by necdin protects neurons against mitochondrial insults
Promotion of mitochondrial biogenesis by necdin protects neurons against mitochondrial insults
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Publisher
London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Neurons rely heavily on mitochondria for their function and survival. Mitochondrial dysfunction contributes to the pathogenesis of neurodegenerative diseases such as Parkinson’s disease. PGC-1α is a master regulator of mitochondrial biogenesis and function. Here we identify necdin as a potent PGC-1α stabilizer that promotes mitochondrial biogenesis...
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Promotion of mitochondrial biogenesis by necdin protects neurons against mitochondrial insults
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TN_cdi_doaj_primary_oai_doaj_org_article_dacc20ca8cd8457c8e9889ba9c258e86
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_dacc20ca8cd8457c8e9889ba9c258e86
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms10943
