HIF2α activation and mitochondrial deficit due to iron chelation cause retinal atrophy
HIF2α activation and mitochondrial deficit due to iron chelation cause retinal atrophy
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Iron accumulation causes cell death and disrupts tissue functions, which necessitates chelation therapy to reduce iron overload. However, clinical utilization of deferoxamine (DFO), an iron chelator, has been documented to give rise to systemic adverse effects, including ocular toxicity. This study provided the pathogenic and molecular basis for DF...
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HIF2α activation and mitochondrial deficit due to iron chelation cause retinal atrophy
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TN_cdi_doaj_primary_oai_doaj_org_article_dad16b5228fa4f2aae01a11f4bb1e21e
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_dad16b5228fa4f2aae01a11f4bb1e21e
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ISSN
1757-4676
E-ISSN
1757-4684
DOI
10.15252/emmm.202216525
