HDAC4 mutant represses chondrocyte hypertrophy by locating in the nucleus and attenuates disease pro...
HDAC4 mutant represses chondrocyte hypertrophy by locating in the nucleus and attenuates disease progression of posttraumatic osteoarthritis
About this item
Full title
Author / Creator
Gu, Xiaodong , Li, Fei , Gao, Yangyang , Che, Xianda and Li, Pengcui
Publisher
England: BioMed Central Ltd
Journal title
Language
English
Formats
Publication information
Publisher
England: BioMed Central Ltd
Subjects
More information
Scope and Contents
Contents
The aim of this study was to evaluate whether histone deacetylase 4 S246/467/632A mutant (m-HDAC4) has enhanced function at histone deacetylase 4 (HDAC4) to attenuate cartilage degeneration in a rat model of osteoarthritis (OA).
Chondrocytes were infected with Ad-m-HDAC4-GFP or Ad-HDAC4-GFP for 24 h, incubated with interleukin-1β (IL-1β 10 ng/mL...
Alternative Titles
Full title
HDAC4 mutant represses chondrocyte hypertrophy by locating in the nucleus and attenuates disease progression of posttraumatic osteoarthritis
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_db6d9ea4441b4db8a3202aab7f83a1f2
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_db6d9ea4441b4db8a3202aab7f83a1f2
Other Identifiers
ISSN
1471-2474
E-ISSN
1471-2474
DOI
10.1186/s12891-021-04947-6
