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Adenoviral vaccine targeting multiple neoantigens as strategy to eradicate large tumors combined wit...

Adenoviral vaccine targeting multiple neoantigens as strategy to eradicate large tumors combined wit...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_db93e80d193c417e9e00b2880fe30cbc

Adenoviral vaccine targeting multiple neoantigens as strategy to eradicate large tumors combined with checkpoint blockade

About this item

Full title

Adenoviral vaccine targeting multiple neoantigens as strategy to eradicate large tumors combined with checkpoint blockade

Publisher

London: Nature Publishing Group UK

Journal title

Nature communications, 2019-06, Vol.10 (1), p.2688-12, Article 2688

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Neoantigens (nAgs) are promising tumor antigens for cancer vaccination with the potential of inducing robust and selective T cell responses. Genetic vaccines based on Adenoviruses derived from non-human Great Apes (GAd) elicit strong and effective T cell-mediated immunity in humans. Here, we investigate for the first time the potency and efficacy o...

Alternative Titles

Full title

Adenoviral vaccine targeting multiple neoantigens as strategy to eradicate large tumors combined with checkpoint blockade

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_db93e80d193c417e9e00b2880fe30cbc

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_db93e80d193c417e9e00b2880fe30cbc

Other Identifiers

ISSN

2041-1723

E-ISSN

2041-1723

DOI

10.1038/s41467-019-10594-2

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