Activation of HIF-1α C-terminal transactivation domain protects against hypoxia-induced kidney injur...
Activation of HIF-1α C-terminal transactivation domain protects against hypoxia-induced kidney injury through hexokinase 2-mediated mitophagy
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Author / Creator
Li, Zuo-Lin , Ding, Lin , Ma, Rui-Xia , Zhang, Yue , Zhang, Yi-Lin , Ni, Wei-Jie , Tang, Tao-Tao , Wang, Gui-Hua , Wang, Bin , Lv, Lin-Li , Wu, Qiu-Li , Wen, Yi and Liu, Bi-Cheng
Publisher
London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Contents
The transcription factor hypoxia-inducible factor-1α (HIF-1α), as a master regulator of adaptive responses to hypoxia, possesses two transcriptional activation domains [TAD, N-terminal (NTAD), and C-terminal (CTAD)]. Although the roles of HIF-1α NTAD in kidney diseases have been recognized, the exact effects of HIF-1α CTAD in kidney diseases are po...
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Full title
Activation of HIF-1α C-terminal transactivation domain protects against hypoxia-induced kidney injury through hexokinase 2-mediated mitophagy
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TN_cdi_doaj_primary_oai_doaj_org_article_db9a7f4687f6468dba20ad9d3c882cc0
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_db9a7f4687f6468dba20ad9d3c882cc0
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ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-023-05854-5
