Inhibitory Effect of PRMT5/MTA Inhibitor on MTAP‐Deficient Glioma May Be Influenced by Surrounding N...
Inhibitory Effect of PRMT5/MTA Inhibitor on MTAP‐Deficient Glioma May Be Influenced by Surrounding Normal Cells
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United States: John Wiley & Sons, Inc
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English
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United States: John Wiley & Sons, Inc
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ABSTRACT
Background
Methylthioadenosine phosphorylase (MTAP) and protein arginine methyltransferase 5 (PRMT5) are considered to be a synthetic lethal pair of targets, due to the fact that deletion of MTAP leads to massive production of methylthioadenosine (MTA) decreasing the activity of PRMT5. In vitro and in vivo experiments have demonstrat...
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Inhibitory Effect of PRMT5/MTA Inhibitor on MTAP‐Deficient Glioma May Be Influenced by Surrounding Normal Cells
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TN_cdi_doaj_primary_oai_doaj_org_article_dbb1f6bf924d4288a0f0de598bd0ea8a
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_dbb1f6bf924d4288a0f0de598bd0ea8a
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ISSN
2045-7634
E-ISSN
2045-7634
DOI
10.1002/cam4.70526
