High-content image-based analysis and proteomic profiling identifies Tau phosphorylation inhibitors...
High-content image-based analysis and proteomic profiling identifies Tau phosphorylation inhibitors in a human iPSC-derived glutamatergic neuronal model of tauopathy
About this item
Full title
Author / Creator
Cheng, Chialin , Reis, Surya A. , Adams, Emily T. , Fass, Daniel M. , Angus, Steven P. , Stuhlmiller, Timothy J. , Richardson, Jared , Olafson, Hailey , Wang, Eric T. , Patnaik, Debasis , Beauchamp, Roberta L. , Feldman, Danielle A. , Silva, M. Catarina , Sur, Mriganka , Johnson, Gary L. , Ramesh, Vijaya , Miller, Bruce L. , Temple, Sally , Kosik, Kenneth S. , Dickerson, Bradford C. and Haggarty, Stephen J.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Mutations in
MAPT
(microtubule-associated protein tau) cause frontotemporal dementia (FTD).
MAPT
mutations are associated with abnormal tau phosphorylation levels and accumulation of misfolded tau protein that can propagate between neurons ultimately leading to cell death (tauopathy). Recently, a p.A152T tau variant was identified as a...
Alternative Titles
Full title
High-content image-based analysis and proteomic profiling identifies Tau phosphorylation inhibitors in a human iPSC-derived glutamatergic neuronal model of tauopathy
Authors, Artists and Contributors
Author / Creator
Reis, Surya A.
Adams, Emily T.
Fass, Daniel M.
Angus, Steven P.
Stuhlmiller, Timothy J.
Richardson, Jared
Olafson, Hailey
Wang, Eric T.
Patnaik, Debasis
Beauchamp, Roberta L.
Feldman, Danielle A.
Silva, M. Catarina
Sur, Mriganka
Johnson, Gary L.
Ramesh, Vijaya
Miller, Bruce L.
Temple, Sally
Kosik, Kenneth S.
Dickerson, Bradford C.
Haggarty, Stephen J.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_dbd7b9c359124c2ab41cec4cd38e2e30
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_dbd7b9c359124c2ab41cec4cd38e2e30
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-021-96227-5
