Synergistic IL-6 and IL-8 paracrine signalling pathway infers a strategy to inhibit tumour cell migr...
Synergistic IL-6 and IL-8 paracrine signalling pathway infers a strategy to inhibit tumour cell migration
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
Following uncontrolled proliferation, a subset of primary tumour cells acquires additional traits/mutations to trigger phenotypic changes that enhance migration and are hypothesized to be the initiators of metastasis. This study reveals an adaptive mechanism that harnesses synergistic paracrine signalling via IL-6/8, which is amplified by cell prol...
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Full title
Synergistic IL-6 and IL-8 paracrine signalling pathway infers a strategy to inhibit tumour cell migration
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TN_cdi_doaj_primary_oai_doaj_org_article_dbe0f12d5d9d4050b25725c41849802f
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_dbe0f12d5d9d4050b25725c41849802f
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms15584
