A conformation-locking inhibitor of SLC15A4 with TASL proteostatic anti-inflammatory activity
A conformation-locking inhibitor of SLC15A4 with TASL proteostatic anti-inflammatory activity
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Author / Creator
Boeszoermenyi, Andras , Bernaleau, Léa , Chen, Xudong , Kartnig, Felix , Xie, Min , Zhang, Haobo , Zhang, Sensen , Delacrétaz, Maeva , Koren, Anna , Hopp, Ann-Katrin , Dvorak, Vojtech , Kubicek, Stefan , Aletaha, Daniel , Yang, Maojun , Rebsamen, Manuele , Heinz, Leonhard X. and Superti-Furga, Giulio
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Dysregulation of pathogen-recognition pathways of the innate immune system is associated with multiple autoimmune disorders. Due to the intricacies of the molecular network involved, the identification of pathway- and disease-specific therapeutics has been challenging. Using a phenotypic assay monitoring the degradation of the immune adapter TASL,...
Alternative Titles
Full title
A conformation-locking inhibitor of SLC15A4 with TASL proteostatic anti-inflammatory activity
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TN_cdi_doaj_primary_oai_doaj_org_article_dc0ae7bb56a6425984c21f37fedceaaa
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_dc0ae7bb56a6425984c21f37fedceaaa
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-42070-3
