Tropinone synthesis via an atypical polyketide synthase and P450-mediated cyclization
Tropinone synthesis via an atypical polyketide synthase and P450-mediated cyclization
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Tropinone is the first intermediate in the biosynthesis of the pharmacologically important tropane alkaloids that possesses the 8-azabicyclo[3.2.1]octane core bicyclic structure that defines this alkaloid class. Chemical synthesis of tropinone was achieved in 1901 but the mechanism of tropinone biosynthesis has remained elusive. In this study, we i...
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Tropinone synthesis via an atypical polyketide synthase and P450-mediated cyclization
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TN_cdi_doaj_primary_oai_doaj_org_article_dca28ed7d56547e7b40945ddfead78c4
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_dca28ed7d56547e7b40945ddfead78c4
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2041-1723
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2041-1723
DOI
10.1038/s41467-018-07671-3
