Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer’s disease in rodent mod...
Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer’s disease in rodent models
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Author / Creator
Daniels, Michael J. D. , Rivers-Auty, Jack , Schilling, Tom , Spencer, Nicholas G. , Watremez, William , Fasolino, Victoria , Booth, Sophie J. , White, Claire S. , Baldwin, Alex G. , Freeman, Sally , Wong, Raymond , Latta, Clare , Yu, Shi , Jackson, Joshua , Fischer, Nicolas , Koziel, Violette , Pillot, Thierry , Bagnall, James , Allan, Stuart M. , Paszek, Pawel , Galea, James , Harte, Michael K. , Eder, Claudia , Lawrence, Catherine B. and Brough, David
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenase-1 (COX-1) and COX-2 enzymes. The NLRP3 inflammasome is a multi-protein complex responsible for the processing of the proinflammatory cytokine interleukin-1β and is implicated in many inflammatory diseases. Here we show that several clinically approved and widely used NSAIDs of th...
Alternative Titles
Full title
Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer’s disease in rodent models
Authors, Artists and Contributors
Author / Creator
Rivers-Auty, Jack
Schilling, Tom
Spencer, Nicholas G.
Watremez, William
Fasolino, Victoria
Booth, Sophie J.
White, Claire S.
Baldwin, Alex G.
Freeman, Sally
Wong, Raymond
Latta, Clare
Yu, Shi
Jackson, Joshua
Fischer, Nicolas
Koziel, Violette
Pillot, Thierry
Bagnall, James
Allan, Stuart M.
Paszek, Pawel
Galea, James
Harte, Michael K.
Eder, Claudia
Lawrence, Catherine B.
Brough, David
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_dca8360eb57c4ee588985f6c192c8a0c
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_dca8360eb57c4ee588985f6c192c8a0c
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms12504
