Methionine-SAM metabolism-dependent ubiquinone synthesis is crucial for ROS accumulation in ferropto...
Methionine-SAM metabolism-dependent ubiquinone synthesis is crucial for ROS accumulation in ferroptosis induction
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Author / Creator
Xia, Chaoyi , Peng, Pinghui , Zhang, Wenxia , Xing, Xiyue , Jin, Xin , Du, Jianlan , Peng, Wanting , Hao, Fengqi , Zhao, Zhexuan , Dong, Kejian , Tian, Miaomiao , Feng, Yunpeng , Ba, Xueqing , Wei, Min and Wang, Yang
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Ferroptosis is a cell death modality in which iron-dependent lipid peroxides accumulate on cell membranes. Cysteine, a limiting substrate for the glutathione system that neutralizes lipid peroxidation and prevents ferroptosis, can be converted by cystine reduction or synthesized from methionine. However, accumulating evidence shows methionine-based...
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Methionine-SAM metabolism-dependent ubiquinone synthesis is crucial for ROS accumulation in ferroptosis induction
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TN_cdi_doaj_primary_oai_doaj_org_article_dcd28ef8fb1f460b9e0ae91b4d0267d7
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_dcd28ef8fb1f460b9e0ae91b4d0267d7
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-53380-5
