Microglial activation, tau and amyloid deposition in TREM2 p.R47H carriers and mild cognitive impair...
Microglial activation, tau and amyloid deposition in TREM2 p.R47H carriers and mild cognitive impairment patients: a multi-modal/multi-tracer PET/MRI imaging study with influenza vaccine immune challenge
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Author / Creator
Cousins, Oliver , Schubert, Julia J. , Chandra, Avinash , Veronese, Mattia , Valkimadi, Polena , Creese, Byron , Khan, Zunera , Arathimos, Ryan , Hampshire, Adam , Rosenzweig, Ivana , Ballard, Clive , Corbett, Anne , Aasland, Dag , Velayudhan, Latha , O’Neill, Michael , Collier, David , Awais, Ramla , Sander, Kerstin , Årstad, Erik , Howes, Oliver , Turkheimer, Federico and Hodges, Angela
Publisher
London: BioMed Central Ltd
Journal title
Language
English
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Publication information
Publisher
London: BioMed Central Ltd
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Scope and Contents
Contents
Background Microglia are increasingly understood to play an important role in the pathogenesis of Alzheimer's disease. The rs75932628 (p.R47H) TREM2 variant is a well-established risk factor for Alzheimer's disease. TREM2 is a microglial cell surface receptor. In this multi-modal/multi-tracer PET/MRI study we investigated the effect of TREM2 p.R47H...
Alternative Titles
Full title
Microglial activation, tau and amyloid deposition in TREM2 p.R47H carriers and mild cognitive impairment patients: a multi-modal/multi-tracer PET/MRI imaging study with influenza vaccine immune challenge
Authors, Artists and Contributors
Author / Creator
Schubert, Julia J.
Chandra, Avinash
Veronese, Mattia
Valkimadi, Polena
Creese, Byron
Khan, Zunera
Arathimos, Ryan
Hampshire, Adam
Rosenzweig, Ivana
Ballard, Clive
Corbett, Anne
Aasland, Dag
Velayudhan, Latha
O’Neill, Michael
Collier, David
Awais, Ramla
Sander, Kerstin
Årstad, Erik
Howes, Oliver
Turkheimer, Federico
Hodges, Angela
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_dcda124d1d09457494573f17556489a7
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_dcda124d1d09457494573f17556489a7
Other Identifiers
ISSN
1742-2094
E-ISSN
1742-2094
DOI
10.1186/s12974-023-02945-0
