DDX5 potentiates HIV-1 transcription as a co-factor of Tat
DDX5 potentiates HIV-1 transcription as a co-factor of Tat
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Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
HIV-1 does not encode a helicase and hijacks those of the cell for efficient replication. We and others previously showed that the DEAD box helicase, DDX5, is an essential HIV dependency factor. DDX5 was recently shown to be associated with the 7SK snRNP. Cellular positive transcription elongation factor b (P-TEFb) is bound in an inactive form with...
Alternative Titles
Full title
DDX5 potentiates HIV-1 transcription as a co-factor of Tat
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TN_cdi_doaj_primary_oai_doaj_org_article_dcfa21ebe39049fb93163139deb473ef
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_dcfa21ebe39049fb93163139deb473ef
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ISSN
1742-4690
E-ISSN
1742-4690
DOI
10.1186/s12977-020-00514-4
