mTOR inhibitors in cancer therapy
mTOR inhibitors in cancer therapy
About this item
Full title
Author / Creator
Publisher
England: Faculty of 1000 Ltd
Journal title
Language
English
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Publication information
Publisher
England: Faculty of 1000 Ltd
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Scope and Contents
Contents
The mammalian target of rapamycin, mTOR, plays key roles in cell growth and proliferation, acting at the catalytic subunit of two protein kinase complexes: mTOR complexes 1 and 2 (mTORC1/2). mTORC1 signaling is switched on by several oncogenic signaling pathways and is accordingly hyperactive in the majority of cancers. Inhibiting mTORC1 signaling...
Alternative Titles
Full title
mTOR inhibitors in cancer therapy
Authors, Artists and Contributors
Author / Creator
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_dd09286fe0f04c808ed9c368d2f95a6f
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_dd09286fe0f04c808ed9c368d2f95a6f
Other Identifiers
ISSN
2046-1402
E-ISSN
2046-1402
DOI
10.12688/f1000research.9207.1
